Postdoctoral position in Bacterial Cell wall Biology and Genetics - Umeå, Sverige - Umeå University

Beskrivning

Project description

The Cava lab at the Laboratory of Molecular Infection Medicine Sweden (MIMS) and the Department of Molecular Biology (Umeå University) conducts research on cell wall biology and genetics in bacteria. Given that the enzymes responsible for producing and maintaining the cell wall are prime targets for many effective antibiotics, understanding the principles of bacterial cell wall homeostasis and adaptability is crucial in tackling emerging resistant infections. Therefore, our primary objective is to enhance our understanding of the various components involved in cell wall biogenesis, remodeling, and regulation, as well as to explore their functions and interactions. Additionally, we aim to transition towards quantitative studies and computational modeling. These investigations hold great potential in identifying novel targets for the development of antimicrobial agents.

Your role will involve characterizing the genetic factors that regulate bacterial cell wall homeostasis across different model bacteria and uncovering the environmental cues that influence regulatory networks governing peptidoglycan plasticity.

Qualifications

The ideal candidate should possess a university degree in Molecular Biology or Microbiology equivalent to a European University PhD at the time of recruitment. We seek individuals who are highly motivated, possess excellent communication skills for interaction with senior colleagues and peers, and demonstrate strong teamwork abilities.

Additionally, the recruited postdoctoral fellow should have prior experience in analytical chemistry, particularly in cell wall analysis. Proficiency in chromatography, mass spectrometry, and associated software such as Empower, UNIFI, and Masslynx is essential. Experience in optimizing and developing new analytical methods, sample preparation and analysis, as well as routine maintenance and troubleshooting of instruments, is highly desirable.

The applicant will focus on investigating bacterial cell wall dynamics and identifying novel cell wall regulatory partners. Proficiency in standard molecular biology and biochemistry techniques, including DNA cloning, protein production, and purification, is required. A solid understanding of microbiology and basic microscopy methods is also necessary. Familiarity with Next Generation Sequencing (NGS) technologies, particularly Tn-seq for high-throughput screening of mutant libraries, is a definite advantage.

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